In Vivo ADME Species : Rodent, Rabbit, dog, monkey and etc Study type : Pharmacokinetics/toxicokinetics (PK/TK), Excretion, mass balance, and expired air collection in rodents, Quantitative tissue distribution (traditional method and QWBA) with dosimetry calculations Bioavailability, Micro-autoradiography (to determine cellular distribution), Placental transfer and milk secretion, Various surgical models, including bile duct cannulation, Metabolite profiling and identification,Radioactivity sample analysis Route of administration ; Oral, Intravenous, Subcutaneous, Intramuscular,(Trans)dermal Intraperitoneal, Oropharyngeal, Intratracheal,Intranasal, Continuous infusion, Intravitreal Ocular, Intrathecal, Portal vein (via access ports), Intraduodenal, Inhalation PK parameters : Dosing interval Cmax, tmax, Cmin, Cmean or Cavg, Volume of distribution, Concentration, Absorption half-life, Absorption rate constant, Elimination half-life, Elimination rate constant, Infusion rate, Area under the curve, Clearance, Bioavailability, and Fluctuation
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