㈜지오비스타

Lead Identification
- Cytotoxicity & Mini AMES Screening
- In vitro dermal absorption
- In vitro Phototoxicity, sensitization, irritation, corrosion etc.
- Screening for Endocrine
- Agonists/Antagonists
- TK screening

Screening Assay Package
- General toxicity ( Rodent, non-rodent including rabbit, dog, monkey and etc)
- Single dose toxicity
- 2 weeks dose range finding

- Genotoxicity
- Chromosomal Aberration Assay
- Ames Test
- micronucleus (MN) test

- Cardiotoxicity
- hERG assay
- binding assay, and patch clamp assay

Safety Pharmacology
- Central Nervous system Evaluation
- Cardiovascular evaluation - Telemetry, hERG assay
- Respiratory System Evaluation
- Bioanalysis - Toxicokinetics evaluation

GLP Regulatory Studies
- IND, NDA, ANDA Safety Evaluation
- Safety Pharmacology
- Repeated dose inhalation
- DART(Segment I, II, III
- Bioanalysis
- Genotoxicity
- Carcinogenicity